A glutamatergic deficiency model of schizophrenia

被引：122

作者：

Carlsson, A ^{[1
]}

Hansson, LO ^{[1
]}

Waters, N ^{[1
]}

Carlsson, ML ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Pharmacol, S-40530 Gothenburg, Sweden

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1999年 / 174卷

关键词：

D O I：

10.1192/S0007125000293574

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Although the presence of hyperdopaminergia has been demonstrated in the brains of people with schizophrenia, at least in some circumstances, other neurotransmitters are important in this disorder. and a glutamatergic deficiency model of schizophrenia is proposed. It is suggested that the amount of sensory input allowed to reach the cerebral cortex is restricted by an inhibitory effect of the striatal complexes on the thalamus, thereby protecting it from being overwhelmed. Several strands of evidence are presented to support the concept that a weakened glutamatergic tone increases the risk of sensory overload and of exaggerated responses in the monoaminergic systems that could result in psychosis.

引用

页码：2 / 6

页数：5

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