Age-related phenotypic alterations in populations of purified human bone precursor cells

被引：13

作者：

Long, MW

Ashcraft, EK

Normalle, D

Mann, KG

机构：

[1] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

[3] Univ Vermont, Dept Biochem, Burlington, VT 05405 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 1999年 / 54卷 / 02期

关键词：

D O I：

10.1093/gerona/54.2.B54

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The ability to purify and characterize phenotypic markers of human bone precursor cells provides an important means to study the basis of age- or disease-related changes in osteogenesis. Utilizing immunologically purified and characterized populations of human bone preosteoblast-like cells, we demonstrate that distinct age-related alterations occur in bone cell phenotypic markers, and additionally document the presence of a subpopulation of elderly individuals who express markedly reduced amounts of bone proteins. These findings provide insights into the early phases of bone cell development, and provide a means for evaluating age- and/or disease-mediated changes in bone cell development.

引用

页码：B54 / B62

页数：9

共 21 条

[1] INCREASE IN SERUM BONE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN WITH AGING IN WOMEN - IMPLICATIONS FOR THE MECHANISM OF AGE-RELATED BONE LOSS [J].