Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques

被引:85
作者
Koegler, FH
Enriori, PJ
Billes, SK
Takahashi, DL
Martin, MS
Clark, RL
Evans, AE
Grove, KL
Cameron, JL
Cowley, MA
机构
[1] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR 97006 USA
[2] Oregon Hlth & Sci Univ, Oregon Natl Primate Res Ctr, Div Reprod Sci, Beaverton, OR 97006 USA
关键词
D O I
10.2337/diabetes.54.11.3198
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Peptide YY(3-36) [PYY(3-36)] is a hormone that is released after meal ingestion that is currently being investigated for the treatment of obesity; however, there are conflicting reports of the effects of PYY(3-36) on energy balance in rodent models. To shed light on this controversy, we studied the effect of PYY(3-36) on food intake and body weight in a nonhuman primate. Intravenous PYY(3-36) infusions before a morning meal transiently suppressed the rate of food intake but did not suppress the evening meal or 24-h intake. Twice-daily or continuous intravenous PYY(3-36) infusions to supraphysiological levels (levels that exceeded normal physiological levels) again suppressed the rate of feeding for the morning but not the evening meal. Twice-daily intravenous PYY(3-36) infusions for 2 weeks significantly decreased body weight in all test animals (average weight loss 1.9%) without changing insulin response to glucose infusion. These results show that endogenous PYY(3-36) may alter morning but not evening meal intake, and supraphysiological doses are required for effective suppression of food intake.
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收藏
页码:3198 / 3204
页数:7
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