Regulation of protein biogenesis at the endoplasmic reticulum membrane

被引:65
作者
Hegde, RS
Lingappa, VR
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
关键词
D O I
10.1016/S0962-8924(99)01504-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The biogenesis of most secretory and membrane proteins involves targeting the nascent protein to the endoplasmic reticulum (ER), translocation across or integration into the ER membrane and maturation into a functional product. The essential machinery that directs these events for model secretory and membrane proteins has been identified, shifting the focus of studies towards the molecular mechanisms by which these core components function. By contrast, regulatory mechanisms that allow certain proteins to serve multiple functions within a cell remain entirely unexplored. This article examines each stage of protein biogenesis as a potential site of regulation that could be exploited by the cell to effectively increase the diversity of functional gene expression.
引用
收藏
页码:132 / 137
页数:6
相关论文
共 61 条
  • [1] A two-step recognition of signal sequences determines the translocation efficiency of proteins
    Belin, D
    Bost, S
    Vassalli, JD
    Strub, K
    [J]. EMBO JOURNAL, 1996, 15 (03) : 468 - 478
  • [2] BELTZER JP, 1991, J BIOL CHEM, V266, P973
  • [3] NOVEL POSTTRANSLATIONAL REGULATION OF TCR EXPRESSION IN CD4+ CD8+ THYMOCYTES INFLUENCED BY CD4
    BONIFACINO, JS
    MCCARTHY, SA
    MAGUIRE, JE
    NAKAYAMA, T
    SINGER, DS
    KLAUSNER, RD
    SINGER, A
    [J]. NATURE, 1990, 344 (6263) : 247 - 251
  • [4] Biogenesis of polytopic membrane proteins: Membrane segments assemble within translocation channels prior to membrane integration
    Borel, AC
    Simon, SM
    [J]. CELL, 1996, 85 (03) : 379 - 389
  • [5] MODULATION OF GENE-EXPRESSION BY CALRETICULIN BINDING TO THE GLUCOCORTICOID RECEPTOR
    BURNS, K
    DUGGAN, B
    ATKINSON, EA
    FAMULSKI, KS
    NEMER, M
    BLEACKLEY, RC
    MICHALAK, M
    [J]. NATURE, 1994, 367 (6462) : 476 - 480
  • [6] CASCARANO J, 1995, HEPATOLOGY, V22, P837, DOI 10.1002/hep.1840220323
  • [7] A GLUCOSE-TRANSPORT PROTEIN EXPRESSED PREDOMINATELY IN INSULIN-RESPONSIVE TISSUES
    CHARRON, MJ
    BROSIUS, FC
    ALPER, SL
    LODISH, HF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2535 - 2539
  • [8] PAUSE TRANSFER - A TOPOGENIC SEQUENCE IN APOLIPOPROTEIN-B MEDIATES STOPPING AND RESTARTING OF TRANSLOCATION
    CHUCK, SL
    LINGAPPA, VR
    [J]. CELL, 1992, 68 (01) : 9 - 21
  • [9] Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
    Coppolino, MG
    Woodside, MJ
    Demaurex, N
    Grinstein, S
    StArnaud, R
    Dedhar, S
    [J]. NATURE, 1997, 386 (6627) : 843 - 847
  • [10] THE SIGNAL SEQUENCE MOVES THROUGH A RIBOSOMAL TUNNEL INTO A NONCYTOPLASMIC AQUEOUS ENVIRONMENT AT THE ER MEMBRANE EARLY IN TRANSLOCATION
    CROWLEY, KS
    REINHART, GD
    JOHNSON, AE
    [J]. CELL, 1993, 73 (06) : 1101 - 1115