Susceptibilities of oral bacteria and yeast to mammalian cathelicidins

被引：53

作者：

Guthmiller, JM ^{[1
]}

Vargas, KG

Srikantha, R

Schomberg, LL

Weistroffer, PL

McCray, PB

Tack, BF

机构：

[1] Univ Iowa, Coll Dent, Dept Periodont, Iowa City, IA 52242 USA

[2] Univ Iowa, Coll Dent, Dept Pediat Dent, Iowa City, IA 52242 USA

[3] Univ Iowa, Coll Dent, Dows Inst Dent Res, Iowa City, IA 52242 USA

[4] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA

[5] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 11期

关键词：

D O I：

10.1128/AAC.45.11.3216-3219.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.

引用

页码：3216 / 3219

页数：4

共 25 条

[1]

Abbott B H, 1977, J West Soc Periodontol Periodontal Abstr, V25, P164

[2] A novel peptide-IgG conjugate, CAP18(106-138)-IgG, that binds and neutralizes endotoxin and kills gram-negative bacteria [J].

Fletcher, MA ;

Kloczewiak, MA ;

Loiselle, PM ;

Ogata, M ;

Vermeulen, MW ;

Zanzot, EM ;

Warren, HS .

JOURNAL OF INFECTIOUS DISEASES, 1997, 175 (03) :621-632

[3] The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders [J].

Frohm, M ;

Agerberth, B ;

Ahangari, G ;

StahleBackdahl, M ;

Liden, S ;

Wigzell, H ;

Gudmundsson, GH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) :15258-15263

[4]

Ganz T, 1997, Curr Opin Hematol, V4, P53

[5]

Ganz T, 1997, SEMIN HEMATOL, V34, P343

[6] Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis [J].

Goldman, MJ ;

Anderson, GM ;

Stolzenberg, ED ;

Kari, UP ;

Zasloff, M ;

Wilson, JM .

CELL, 1997, 88 (04) :553-560

[7] Oropharyngeal yeast flora and fluconazole resistance in HIV-infected patients receiving long-term continuous versus intermittent fluconazole therapy [J].

Heald, AE ;

Cox, GM ;

Schell, WA ;

Bartlett, JA ;

Perfect, JR .

AIDS, 1996, 10 (03) :263-268

[8] Critical role of lipid composition in membrane permeabilization by rabbit neutrophil defensins [J].

Hristova, K ;

Selsted, ME ;

White, SH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24224-24233

[9]

KENNEDY MJ, 1992, J MED VET MYCOL, V30, P95

[10] STRUCTURAL FEATURES OF SALIVARY FUNCTION [J].

LAMKIN, MS ;

OPPENHEIM, FG .

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (3-4) :251-259

← 1 2 3 →