Bisphenol A (BPA) and cell signaling pathways

被引：340

作者：

Murata, Masaharu ^{[1
]}

Kang, Jeong-Hun ^{[2
]}

机构：

[1] Kyushu Univ, Fac Med Sci, Dept Adv Med Initiat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[2] Natl Cerebral & Cardiovasc Ctr Res Inst, Div Biopharmaceut & Pharmacokinet, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

来源：

BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 01期

关键词：

Bisphenol A; Brain; Cancer; Cell signaling; Immune response; Inflammation; Metabolic disease; Nervous system; Reproductive toxicity; ESTROGEN-RECEPTOR-ALPHA; HUMAN BREAST-CANCER; ENDOCRINE-DISRUPTING CHEMICALS; DENDRITIC SPINE DENSITY; CYCLOOXYGENASE-2; UP-REGULATION; ACTIVATED PROTEIN-KINASES; MAMMARY-GLAND DEVELOPMENT; REDUCES SPERM QUALITY; GLYCOPROTEIN; 75; KDA; FACTOR-I RECEPTOR;

D O I：

10.1016/j.biotechadv.2017.12.002

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Bisphenol A (BPA; 4,4'-isopropylidenediphenol) is an endocrine disruptor that is used as a material for the production of phenol resins, polyacrylates, polyesters, epoxy resins, and polycarbonate plastics. Endocrine disruptive or toxic effects of BPA on living organisms through a number of cell signaling pathways have been reported. BPA induces carcinogenesis, reproductive toxicity, abnormal inflammatory or immune response, and developmental disorders of brain or nervous system through various cell signaling pathways. This review considers the literature concerning BPA and its association with cancer-related cell signaling pathways, reproductive toxicity-related cell signaling pathways, inflammatory or immune response-related cell signaling pathways, and brain and nervous system-related cell signaling pathways.

引用

页码：311 / 327

页数：17

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