The design and synthesis of novel adenosine agonists

被引：12

作者：

Scammells, PJ

Baker, SP

Bellardinelli, L

Olsson, RA

Russell, RA

Knevitt, SA

机构：

[1] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,DEPT PHARMACOL,GAINESVILLE,FL 32610

[2] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,DEPT MED,GAINESVILLE,FL 32610

[3] UNIV S FLORIDA,DEPT INTERNAL MED,TAMPA,FL 33612

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 07期

关键词：

D O I：

10.1016/0960-894X(96)00111-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 2R and 2S-endo isomers of N-6-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the At adenosine receptor. The 2S-endo isomer was equipotent to N-6-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer. Copyright (C) 1996 Elsevier Science Ltd

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页码：811 / 814

页数：4

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