Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis

被引：21

作者：

Pendergast, AM ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

来源：

NATURE CELL BIOLOGY | 2005年 / 7卷 / 03期

关键词：

D O I：

10.1038/ncb0305-213

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nuclear accumulation of the c-Abl tyrosine kinase is associated with a pro-apoptotic response after DNA damage, but the mechanism regulating c-Abl nuclear localization is unclear. DNA damage and other stress signals are now shown to induce phosphorylation of 14-3-3 proteins by the c-Junamino-terminal kinase, disrupting a c-Abl/14-3-3 cytoplasmic complex, and liberating c-Abl for translocation to the nucleus.

引用

页码：213 / 214

页数：2

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