Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

被引：1629

作者：

Gao, Jianjun ^{[1
]}

Tian, Zhenxue ^{[2
]}

Yang, Xu ^{[2
]}

机构：

[1] Qingdao Univ, Sch Pharm, Dept Pharmacol, Qingdao, Shandong, Peoples R China

[2] Qingdao Municipal Hosp, Dept Pharm, Qingdao, Peoples R China

来源：

BIOSCIENCE TRENDS | 2020年 / 14卷 / 01期

关键词：

COVID-19; SARS-CoV-2; 2019-nCoV; pneumonia; chloroquine; DRUG;

D O I：

10.5582/bst.2020.01047

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

引用

页码：72 / 73

页数：2

共 4 条

[1] Drug treatment options for the 2019-new coronavirus (2019-nCoV) [J].

Lu, Hongzhou .

BIOSCIENCE TRENDS, 2020, 14 (01) :69-71

[2] Effects of chloroquine on viral infections: an old drug against today's diseases? [J].

Savarino, A ;

Boelaert, JR ;

Cassone, A ;

Majori, G ;

Cauda, R .

LANCET INFECTIOUS DISEASES, 2003, 3 (11) :722-727

[3] Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [J].

Wang, Manli ;

Cao, Ruiyuan ;

Zhang, Leike ;

Yang, Xinglou ;

Liu, Jia ;

Xu, Mingyue ;

Shi, Zhengli ;

Hu, Zhihong ;

Zhong, Wu ;

Xiao, Gengfu .

CELL RESEARCH, 2020, 30 (03) :269-271

[4] Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model [J].

Yan, Yiwu ;

Zou, Zhen ;

Sun, Yang ;

Li, Xiao ;

Xu, Kai-Feng ;

Wei, Yuquan ;

Jin, Ningyi ;

Jiang, Chengyu .

CELL RESEARCH, 2013, 23 (02) :300-302

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