The continuing evolution of shotgun proteomics

被引：64

作者：

Swanson, SK ^{[1
]}

Washburn, MP ^{[1
]}

机构：

[1] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 10期

关键词：

D O I：

10.1016/S1359-6446(05)03450-1

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Shotgun proteomics has emerged as a powerful approach for the analysis of complex protein mixtures, including biofluids, tissues, cells, organelles or protein complexes. Having evolved from the integration of chromatography and mass spectrometry, innovations in sample preparation, multidimensional chromatography, mass spectrometry and proteomic informatics continually facilitate, enable and challenge shotgun proteomics. As a result, shotgun proteomics continues to evolve and enable new areas of biological research, and is beginning to impact human disease diagnosis and therapeutic intervention.

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收藏

页码：719 / 725

页数：7

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