Reinioside C, a triterpene saponin of Polygala aureocauda Dunn, exerts hypolipidemic effect on hyperlipidemic mice.

被引：40

作者：

Li, Hao ^{[1
]}

Wang, Qiu-Juan ^{[1
]}

Zhu, Dan-Ni ^{[2
]}

Yang, Yong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Physiol, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Dept TCM Recipe, Nanjing 210009, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 02期

关键词：

Polygala aureocauda Dunn; reinioside C; OxLDL; Ca2+; hyperlipidemia;

D O I：

10.1002/ptr.2262

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reinioside C is a triterpene saponin from the the root of Polygala aureocauda Dunn (PAD). This study examined the effects of reinioside C on hyperlipidemic mice in vivo and endothelium cells, macrophages and smooth muscle cells in vitro. Mice were given a hyperlipidemic diet for 30 days, then administered reinioside C (4, 8, 16 mg/kg/day, p.o.) for 30 days. Then the serum lipid, superoxide dismutase (SOD), malonaldehyde (MDA), the total cholesterol (TC) and triglyceride (TG) in the liver extract were measured. Human umbilical vein endothelial (HUVECs), peritonea] macrophages and smooth muscle cells (SMCs) pre-treated with reinioside C were treated with oxidized low-density lipoprotein (OxLDL). The results showed that reinioside C decreased serum and liver tissue lipid profiles in hyperlipidemic mice. Moreover, reinioside C protected the HUVECs against the Ox-LDL induced LDH leakage and exerted a protective effect on oxidative lesions induced by OxLDL, inhibited cholesteryl ester accumulation in macrophages, and decreased [Ca2+](i) and SMC proliferation in vitro. Based on these results, it is suggested that reinioside C is a promising hypolipidemic candidate. Copyright (C) 2007 John Wiley & Sons, Ltd.

引用

页码：159 / 164

页数：6

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