Hidden Immunotherapy Targets Challenge Dogma

被引：13

作者：

Ferrone, Soldano ^{[1
]}

机构：

[1] Univ Pittsburgh, Inst Canc, Pittsburgh, PA 15213 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2011年 / 3卷 / 99期

关键词：

MONOCLONAL-ANTIBODIES; THERAPY; CELLS;

D O I：

10.1126/scitranslmed.3002821

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue of Science Translational Medicine, Guo et al. discuss the intriguing possibility that intracellular tumor antigen-specific monoclonal antibodies (mAbs) inhibit tumor growth and metastasis and prolong survival of tumor-bearing mice. Here, I discuss the implications of using intracellular targets in mAb-based immunotherapy as well as the possible underlying mechanisms of action.

引用

页数：3

共 12 条

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