Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceus

被引：57

作者：

López-Gresa, MP ^{[1
]}

González, MC ^{[1
]}

Primo, J ^{[1
]}

Moya, P ^{[1
]}

Romero, V ^{[1
]}

Estornell, E ^{[1
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Bioquim & Biol Mol, E-46100 Burjassot, Valencia, Spain

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 06期

关键词：

Aspergillus ochraceus; alkaloids; benzodiazepine; circumdatin; flavacol; stephacidin A; mitochondrial respiratory chain inhibitors;

D O I：

10.1038/ja.2005.54

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Circumdatin H (1), a new alkaloid from the culture broth of Aspergillus ochraceus, has been isolated, together with a known circumdatin, circumdatin E (2) and other known compounds: flavacol (3) and stephacidin A (4). The structure of 1 was established on the basis of chemical and spectral evidence. All of these alkaloids showed biological activity as inhibitors of the mammalian mitochondrial respiratory chain.

引用

页码：416 / 419

页数：4

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