Elevated Plasma Homocysteine Is Associated with Increased Brain Atrophy Rates in Older Subjects with Mild Hypertension

被引：45

作者：

Narayan, Sunil K. ^{[1
]}

Firbank, Michael J. ^{[1
]}

Saxby, Brian K. ^{[3
]}

Stansby, Gerard ^{[2
]}

Hansrani, Monica ^{[2
]}

O'Brien, John T. ^{[1
]}

Ford, Gary A. ^{[1
]}

机构：

[1] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England

[3] Cognit Drug Res Ltd, Goring On Thames, England

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2011年 / 31卷 / 05期

关键词：

Homocysteine; Folate; B12; Brain atrophy; White matter lesions; Hypertension; WHITE-MATTER HYPERINTENSITIES; RISK FACTOR; COGNITIVE DECLINE; FOLATE; DISEASE; HIPPOCAMPAL; DEMENTIA; LESIONS; SCOPE; MRI;

D O I：

10.1159/000328118

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

We determined using serial MR imaging whether raised plasma homocysteine levels are associated with increased brain atrophy, white matter lesion (WML) progression or incidence of silent brain infarcts (SBIs) in older hypertensive subjects. Brain atrophy rates (0.58 +/- 0.48% per year, mean +/- SD) were significantly correlated with homocysteine (beta = 0.46, p = 0.001 homocysteine; beta = 0.44, p = 0.007 homocysteine/folate/B12 models) but not with folate or B12 levels. Progression of WML (0.08 +/- 0.16%) was not associated with homocysteine level (B = 0.01, p = 0.29). New SBIs were uncommon. In older hypertensive individuals, plasma homocysteine levels are associated with increased rates of whole-brain atrophy but not WML progression. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：341 / 348

页数：8

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