Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein E by hepatocytes

被引：10

作者：

Arai, H

Uchida, K

Nakamura, K ^{[1
]}

机构：

[1] Yamaguchi Univ, Sch Med, Dept Biochem & Biomol Recognit, Ube, Yamaguchi 7558505, Japan

[2] Nagoya Univ, Sch Agr Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 09期

关键词：

acrolein; apolipoprotein E; ascorbate; hepatocyte; very low density lipoprotein;

D O I：

10.1271/bbb.69.1760

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acrolein modification of apolipoprotein (apo) E in human very low density lipoprotein (VLDL) was suppressed by ascorbate. Acrolein-modified apoE in VLDL was not taken up by human hepatoma cell whereas unmodified apoE in the presence of ascorbate was taken up. These results suggest that ascorbate can play an important role in maintaining proper lipoprotein metabolism by the antioxidant effect.

引用

页码：1760 / 1762

页数：3

共 13 条

[1] Oxidative modification of apolipoprotein E in human very-low-density lipoprotein and its inhibition by glycosaminoglycans [J].