RNA repair: Damage control

被引：66

作者：

Bellacosa, A ^{[1
]}

Moss, EG ^{[1
]}

机构：

[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(03)00408-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.

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页码：R482 / R484

页数：3

相关论文

共 20 条

[1] Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA [J].

Aas, PA ;

Otterlei, M ;

Falnes, PO ;

Vågbo, CB ;

Skorpen, F ;

Akbari, M ;

Sundheim, O ;

Bjorås, M ;

Slupphaug, G ;

Seeberg, E ;

Krokan, HE .

NATURE, 2003, 421 (6925) :859-863

[2]

Aravind L., 2001, GENOME BIOL, V2, p7.1

[3] A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity [J].

Birrell, GW ;

Giaever, G ;

Chu, AM ;

Davis, RW ;

Brown, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) :12608-12613

[4] THE ROLE OF P53 IN REGULATING GENOMIC STABILITY WHEN DNA AND RNA-SYNTHESIS ARE INHIBITED [J].

CHERNOVA, OB ;

CHERNOV, MV ;

AGARWAL, ML ;

TAYLOR, WR ;

STARK, GR .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (10) :431-434

[5] Reversal of DNA alkylation damage by two human dioxygenases [J].

Duncan, T ;

Trewick, SC ;

Koivisto, P ;

Bates, PA ;

Lindahl, T ;

Sedgwick, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) :16660-16665

[6] AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli [J].

Falnes, PO ;

Johansen, RF ;

Seeberg, E .

NATURE, 2002, 419 (6903) :178-182

[7]

GLAZER RI, 1982, MOL PHARMACOL, V21, P468

[8]

He WH, 2001, GENETICS, V158, P1445

[9] Cisplatin inhibits protein synthesis in rabbit reticulocyte lysate by causing an arrest in elongation [J].

Heminger, KA ;

Hartson, SD ;

Rogers, J ;

Matts, RL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1997, 344 (01) :200-207

[10] Transcriptional activation of the MDR1 gene by UV irradiation - Role of NF-Y and Sp1 [J].

Hu, Z ;

Jin, SK ;

Scotto, KW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (04) :2979-2985