Manifestations of systemic autoimmunity in vaccinated salmon

被引：47

作者：

Haugarvoll, Erlend ^{[1
]}

Bjerkas, Inge ^{[1
]}

Szabo, Nancy J. ^{[4
]}

Satoh, Minoru ^{[2
,3
]}

Koppang, Erling O. ^{[1
]}

机构：

[1] Norwegian Sch Vet Sci, Sect Anat & Pathol, Dept Basic Sci & Aquat Med, N-0033 Oslo, Norway

[2] Univ Florida, Div Rheumatol & Clin Immunol, Dept Med, Gainesville, FL 32610 USA

[3] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

[4] Univ Florida, Analyt Toxicol Core Lab, Dept Physiol Sci, Gainesville, FL 32610 USA

来源：

VACCINE | 2010年 / 28卷 / 31期

关键词：

Systemic autoimmunity; Vaccination; Salmo salar; OIL-ADJUVANTED VACCINES; FARMED ATLANTIC SALMON; SALAR L; INTRAPERITONEAL INJECTION; LUPUS-ERYTHEMATOSUS; CELLS; PRISTANE; FISH; IMMUNOGLOBULIN; FURUNCULOSIS;

D O I：

10.1016/j.vaccine.2010.05.032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of systemic autoimmunity may result as an undesired side-effect following vaccination, and this condition was recently shown to occur in farmed salmon (Salmo salar). Several of previously reported side-effects following vaccination of fish should therefore be reviewed in the light of this condition. Here, organs and pathological changes in three separate groups of fish severely affected by vaccination were investigated by different morphological methods (n = 84). Granulomas or microgranulomas were observed at the injection site and in several organs. Mott cells were observed in all tissues examined. Pannus-like changes with lymphocyte infiltrates were observed in spines. In conclusion, the reactions following vaccination were of a systemic nature that may be explained by a pathogenetic mechanism caused by systemic autoimmunity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4961 / 4969

页数：9

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