Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis

被引:5
作者
Arnon, S
Litmanovits, I
Regev, R
Elpeleg, O
Dolfin, T
机构
[1] Meir Hosp, Dept Pediat, IL-44281 Kefar Sava, Israel
[2] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[3] Shaare Zedek Hosp, Metab Unit, Jerusalem, Israel
关键词
neonatal sepsis; acidosis; dichloroacetate;
D O I
10.1097/00006454-200102000-00021
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We describe a preterm neonate with documented group B Streptococcus sepsis and associated metabolic acidosis whose lactic acidemia was refractory to conventional sodium bicarbonate therapy but responded well to dichloroacetate treatment.
引用
收藏
页码:218 / 219
页数:2
相关论文
共 4 条
[1]   Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability [J].
Gore, DC ;
Jahoor, F ;
Hibbert, JM ;
DeMaria, EJ .
ANNALS OF SURGERY, 1996, 224 (01) :97-102
[2]   LACTIC-ACIDOSIS AND HYPOGLYCEMIA IN CHILDREN WITH SEVERE MALARIA - PATHOPHYSIOLOGICAL AND PROGNOSTIC-SIGNIFICANCE [J].
KRISHNA, S ;
WALLER, DW ;
TERKUILE, F ;
KWIATKOWSKI, D ;
CRAWLEY, J ;
CRADDOCK, CFC ;
NOSTEN, F ;
CHAPMAN, D ;
BREWSTER, D ;
HOLLOWAY, PA ;
WHITE, NJ .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1994, 88 (01) :67-73
[3]   Treatment of congenital lactic acidosis with dichloroacetate [J].
Stacpoole, PW ;
Barnes, CL ;
Hurbanis, MD ;
Cannon, SL ;
Kerr, DS .
ARCHIVES OF DISEASE IN CHILDHOOD, 1997, 77 (06) :535-541
[4]   A CONTROLLED CLINICAL-TRIAL OF DICHLOROACETATE FOR TREATMENT OF LACTIC-ACIDOSIS IN ADULTS [J].
STACPOOLE, PW ;
WRIGHT, EC ;
BAUMGARTNER, TG ;
BERSIN, RM ;
BUCHALTER, S ;
CURRY, SH ;
DUNCAN, CA ;
HARMAN, EM ;
HENDERSON, GN ;
JENKINSON, S ;
LACHIN, JM ;
LORENZ, A ;
SCHNEIDER, SH ;
SIEGEL, JH ;
SUMMER, WR ;
THOMPSON, D ;
WOLFE, CL ;
ZOROVICH, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (22) :1564-1569