Opinion - Reassessing the function of immune-complex retention by follicular dendritic cells

被引：96

作者：

Haberman, AM ^{[1
]}

Shlomchik, MJ

机构：

[1] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1178

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The close association of follicular dendritic cells (FDCs) and germinal-centre B cells has fostered the idea that B-cell recognition of retained antigen that is presented on the surface of FDCs is important for affinity maturation and memory B-cell development. We argue that the retention of immune complexes is not required for germinal-centre development, affinity maturation and memory B-cell maintenance. Instead, it is probable that FDCs support B-cell proliferation and differentiation in a non-specific manner. Other potential roles of immune complexes retained by FDCs are discussed.

引用

页码：757 / 764

页数：8

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