Effect of recombinant human insulin-like growth factor-I on expression of glucose transporters, GLUT 2 and GLUT 4, in streptozotocin-diabetic rat

被引：13

作者：

Asada, T ^{[1
]}

Ogawa, T

Iwai, M

Kobayashi, M

机构：

[1] Fujisawa Pharmaceut Co Ltd, Mol Biol Res Labs, Osaka 5328514, Japan

[2] Marine Tech Coll, Dept Chem, Ashiya 6590026, Japan

[3] Fujisawa Pharmaceut Co Ltd, Pharmaceut Res Labs, Osaka 5328514, Japan

[4] Northwestern Univ, Fujisawa Res Inst Amer Inc, Evanston, IL 60201 USA

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 78卷 / 01期

关键词：

glucose transporter; reverse transcription-polymerase chain reaction (RT-PCR); immunohistochemistry;

D O I：

10.1254/jjp.78.63

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the effect of recombinant insulin-like growth factor-I (rhIGF-I) on the expression of glucose transporters, GLUT 2 in the liver and GLUT 4 in the heart, in streptozotocin (STZ)-diabetic rats by the reverse transcription-polymerase chain reaction (RT-P CR) and immunohistochemistry. GLUT 2 and its mRNA in the liver was elevated, whereas GLUT 4 and its mRNA in the heart were decreased in STZ-diabetic rats. A two-week treatment with rhIGF-I mostly restored the expression of GLUT 2 and GLUT 4 to normal rat level. We demonstrated that the effect of IGF-I on the expressions of GLUTs was almost the same as that of insulin.

引用

页码：63 / 67

页数：5

共 15 条

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