Subgenotype diversity of hepatitis B virus American genotype F in Amerindians from Venezuela and the general population of Colombia

被引:71
作者
Devesa, M.
Loureiro, C. L.
Rivas, Y.
Monsalve, F.
Cardona, N.
Duarte, M. C.
Poblete, F.
Gutierrez, M. F.
Botto, C.
Pujol, F. H.
机构
[1] IVIC, CMBC, Lab Virol Mol, Caracas, Venezuela
[2] LUZ, Maracaibo, Venezuela
[3] CAICET, Puerto Ayacucho, Venezuela
[4] Univ Javeriana, Bogota, Colombia
关键词
hepatitis B virus; genotype; Amerindians;
D O I
10.1002/jmv.21024
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学]; 100705 [微生物与生化药学];
摘要
The objective of this study was the evaluation of the genetic diversity found in HBV circulating among Venezuelan Amerindians and the general population in Colombia. Phylogenetic analysis of the S region in 194 isolates showed that genotype F is highly predominant in Colombia and Venezuela. This might be related to the genetic background of the population. F3 is the main subgenotype which circulates in both countries. Phylogenetic analysis of 61 complete genome sequences of HBV American genotypes confirms the presence of two genotypes F and H, and 4 F subgenotypes. In Venezuela, subgenotypes F1, F2, and F3 circulate in East and West Amerindians, while only F3 was found among South Amerindians. Japreira community derived from Yucpa Amerindians around 150 years ago. However, several Japreira HBV sequences were forming a clade that can be classified as subgenotype 2b, differing from Yucpa sequences that belong mainly to subgenotype F3. The apparent absence of correlation between the phylogenetic groupings of HBV isolates with the ethnical origin in aboriginal populations might be suggesting a recent origin of HBV American subgenotypes, or a genetic drift effect.
引用
收藏
页码:20 / 26
页数:7
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