Dimeric β-turn peptidomimetics as ligands for the neurotropin receptor TrkC

被引：18

作者：

Zhang, AJ

Khare, S

Gokulan, K

Linthicum, DS

Burgess, K

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

[2] Texas A&M Univ, Ctr Macromol Design, Dept Pathobiol, College Stn, TX 77843 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)00618-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve dimeric peptidomimetics 1 were prepared via a divergent-convergent strategy. These peptidomimetics incorporated the same amino acids as i+1 and i+2 residues in key beta -turns of the neurotrophin NT-3. Cytosensor microphysiometry was used to gauge the effects of the dimers 1 on cells that overexpress the NT-3 receptor, TrkC. Increases in extracellular acidification rates were observed for some monomers 3, but the active dimers gave greater effects. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：207 / 210

页数：4

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