Altered brain sodium channel transcript levels in human epilepsy

被引：45

作者：

Lombardo, AJ

Kuzniecky, R

Powers, RE

Brown, GB

机构：

[1] UNIV ALABAMA, DEPT NEUROL, UAB EPILEPSY CTR, BIRMINGHAM, AL 35294 USA

[2] UNIV ALABAMA, DEPT PATHOL, BIRMINGHAM, AL 35294 USA

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 35卷 / 1-2期

关键词：

sodium channel; ion channel; epilepsy; ligase detection reaction; mRNA quantitation;

D O I：

10.1016/0169-328X(95)00194-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Normal, and perhaps pathological, characteristics of neuronal excitability are related to the distribution and density of voltage-gated ion channels such as the sodium channel. We studied normal and epileptic human brain using the ligase detection reaction to measure the relative quantities of mRNAs encoding sodium channel subtypes 1 and 2. Normal brains exhibited characteristic 1:2 ratios which varied by brain region, but the ratios were invariate among individuals. These normal values were altered as much as threefold in anatomically corresponding regions of epileptic brain tissues. Changes of this magnitude in such a highly conserved value support a potential role for sodium channels in the pathophysiology of epilepsy.

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页码：84 / 90

页数：7

相关论文

共 41 条

[1] PRIMARY STRUCTURE, CHROMOSOMAL LOCALIZATION, AND FUNCTIONAL EXPRESSION OF A VOLTAGE-GATED SODIUM-CHANNEL FROM HUMAN BRAIN [J].

AHMED, CMI ;

WARE, DH ;

LEE, SC ;

PATTEN, CD ;

FERRERMONTIEL, AV ;

SCHINDER, AF ;

MCPHERSON, JD ;

WAGNERMCPHERSON, CB ;

WASMUTH, JJ ;

EVANS, GA ;

MONTAL, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (17) :8220-8224

[2] POSTNATAL-DEVELOPMENT OF A PERSISTENT NA+ CURRENT IN PYRAMIDAL NEURONS FROM RAT SENSORIMOTOR CORTEX [J].

ALZHEIMER, C ;

SCHWINDT, PC ;

CRILL, WE .

JOURNAL OF NEUROPHYSIOLOGY, 1993, 69 (01) :290-292

[3] A RAT-BRAIN NA+ CHANNEL ALPHA-SUBUNIT WITH NOVEL GATING PROPERTIES [J].

AULD, VJ ;

GOLDIN, AL ;

KRAFTE, DS ;

MARSHALL, J ;

DUNN, JM ;

CATTERALL, WA ;

LESTER, HA ;

DAVIDSON, N ;

DUNN, RJ .

NEURON, 1988, 1 (06) :449-461

[4] ELECTROPHYSIOLOGICAL PROPERTIES AND SYNAPTIC RESPONSES IN THE DEEP LAYERS OF THE HUMAN EPILEPTOGENIC NEOCORTEX INVITRO [J].

AVOLI, M ;

OLIVIER, A .

JOURNAL OF NEUROPHYSIOLOGY, 1989, 61 (03) :589-606

[5]

AVOLI M, 1994, EXP BRAIN RES, V98, P135

[6] GENETIC-DISEASE DETECTION AND DNA AMPLIFICATION USING CLONED THERMOSTABLE LIGASE [J].

BARANY, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) :189-193

[7] DIFFERENTIAL REGULATION OF 3 SODIUM-CHANNEL MESSENGER-RNAS IN THE RAT CENTRAL NERVOUS-SYSTEM DURING DEVELOPMENT [J].

BECKH, S ;

NODA, M ;

LUBBERT, H ;

NUMA, S .

EMBO JOURNAL, 1989, 8 (12) :3611-3616

[8] SODIUM-CHANNEL MESSENGER-RNAS IN CULTURED SPINAL-CORD ASTROCYTES - IN-SITU HYBRIDIZATION IN IDENTIFIED CELL-TYPES [J].

BLACK, JA ;

YOKOYAMA, S ;

WAXMAN, SG ;

OH, Y ;

ZUR, KB ;

SONTHEIMER, H ;

HIGASHIDA, H ;

RANSOM, BR .

MOLECULAR BRAIN RESEARCH, 1994, 23 (03) :235-245

[9]

BLACK JA, 1994, J NEUROCHEM, V62, pS103

[10] CHARACTERIZATION OF THE RELATION BETWEEN SODIUM-CHANNELS AND ELECTRICAL-ACTIVITY IN CULTURED RAT SKELETAL MYOTUBES - REGULATORY ASPECTS [J].

BRODIE, C ;

BRODY, M ;

SAMPSON, SR .

BRAIN RESEARCH, 1989, 488 (1-2) :186-194

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