Macrophage activating effects of new alkamides from the roots of Echinacea species

被引：57

作者：

Chen, Y ^{[1
]}

Fu, T ^{[1
]}

Tao, T ^{[1
]}

Yang, JH ^{[1
]}

Chang, Y ^{[1
]}

Wang, MH ^{[1
]}

Kim, L ^{[1
]}

Qu, LP ^{[1
]}

Cassady, J ^{[1
]}

Scalzo, R ^{[1
]}

Wang, XP ^{[1
]}

机构：

[1] Gaia Herbs Inc, Brevard, NC 28712 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 05期

关键词：

D O I：

10.1021/np040245f

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of the roots of Echinacea angustifolia, E. purpurea, and E. pallida yielded two new alkamides, identified by analysis of spectroscopic data and comparison with reported alkamides. The new compounds were dodeca-2Z,4E,10Z-trien-8-ynoic acid isobutylamide (1) from E. angustifolia and dodeca-2Z,4E-diene-8,10-diynoic acid isobutylamide (2) from E. purpurea and E. pallida. These two components, as well as previously identified alkamides, exerted inhibition on LPS-mediated activation of a murine macrophage line, RAW264.7. These data suggest that these alkamides may have anti-inflammatory activity. The cytotoxicity of these alkamides using MTT assays was also investigated.

引用

页码：773 / 776

页数：4

共 9 条

[1] ECHINACEA .5. TLC AND HPLC ANALYSIS OF ALKAMIDES IN ECHINACEA DRUGS [J].