Matrix reloaded to circulation hits the tumor target

被引：8

作者：

Wickström, SA ^{[1
]}

Keski-Oja, J

Alitalo, K

机构：

[1] Univ Helsinki, Biomed Helsinki, Dept Pathol, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Biomed Helsinki, Dept Virol, FIN-00014 Helsinki, Finland

[3] Univ Helsinki Hosp, Mol Canc Biol Lab, FIN-00014 Helsinki, Finland

[4] Univ Helsinki Hosp, Haartman Inst, FIN-00014 Helsinki, Finland

来源：

CANCER CELL | 2003年 / 3卷 / 06期

关键词：

D O I：

10.1016/S1535-6108(03)00143-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Proteolytic fragments of various components of the extracellular matrix exhibit antiangiogenic activity via interaction with endothelial cell surface integrins. Kalluri and coworkers (Hamano et al., 2003; this issue of Cancer Cell) use gene-targeted mice to show a physiological role for a carboxy-terminal fragment of collagen IV in the regulation of tumor angiogenesis.

引用

页码：513 / 514

页数：2

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