At the interface of sensory and motor dysfunctions and Alzheimer's disease

被引：493

作者：

Albers, Mark W. ^{[1
]}

Gilmore, Grover C. ^{[2
]}

Kaye, Jeffrey ^{[3
]}

Murphy, Claire ^{[4
]}

Wingfield, Arthur ^{[5
,6
]}

Bennett, David A. ^{[7
]}

Boxer, Adam L. ^{[8
]}

Buchman, Aron S. ^{[7
]}

Cruickshanks, Karen J. ^{[9
,10
]}

Devanand, Davangere P. ^{[11
]}

Duffy, Charles J. ^{[12
]}

Gall, Christine M. ^{[13
]}

Gates, George A. ^{[14
]}

Granholm, Ann-Charlotte ^{[15
,16
]}

Hensch, Takao ^{[17
]}

Holtzer, Roee ^{[18
]}

Hyman, Bradley T. ^{[1
]}

Lin, Frank R. ^{[19
]}

Mc Kee, Ann C. ^{[20
,21
]}

Morris, John C. ^{[22
]}

Petersen, Ronald C. ^{[23
]}

Silbert, Lisa C. ^{[3
]}

Stuble, Robert G. ^{[24
]}

Trojanowski, John Q. ^{[25
,26
]}

Verghese, Joe ^{[18
]}

Wilson, Donald A. ^{[27
]}

Xu, Shunbin ^{[7
]}

Zhang, Li I. ^{[28
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Neurol, Charlestown, MA 02129 USA

[2] Case Western Reserve Univ, Jack Joseph & Morton Mandel Sch Appl Social Sci, Cleveland, OH 44106 USA

[3] Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA

[4] San Diego State Univ, SDSU UCSD Joint Doctoral Program Clin Psychol, San Diego, CA 92182 USA

[5] Brandeis Univ, Volen Natl Ctr Complex Syst, Waltham, MA USA

[6] Brandeis Univ, Dept Psychol, Waltham, MA USA

[7] Rush Univ, Ctr Med, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[8] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[9] Univ Wisconsin, Sch Med & Publ Hlth, Dept Ophthalmol & Visual Sci, Madison, WI USA

[10] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA

[11] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA

[12] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA

[13] Univ Calif Irvine, Dept Anat & Neurobiol, Irvine, CA 92717 USA

[14] Univ Washington, Bloedel Hearing Res Ctr, Seattle, WA 98195 USA

[15] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA

[16] Med Univ S Carolina, Ctr Aging, Charleston, SC 29425 USA

[17] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[18] Yeshiva Univ, Albert Einstein Coll Med, Dept Neurol, Bronx, NY USA

[19] Johns Hopkins Sch Med, Div Otol Neurotol & Skull Base Surg, Baltimore, MD USA

[20] Boston Univ, Sch Med, Dept Neurol, Bedford, MA USA

[21] Boston Univ, Sch Med, Dept Pathol, Bedford, MA USA

[22] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[23] Mayo Clin, Coll Med, Mayo Alzheimers Dis Res Ctr, Rochester, MN USA

[24] So Illinois Univ, Sch Med, Ctr Alzheimer Dis & Related Disorders, Springfield, IL USA

[25] Univ Penn, Perelman Sch Med, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[26] Univ Penn, Perelman Sch Med, Inst Aging, Philadelphia, PA 19104 USA

[27] Nathan S Kline Inst Psychiat Res, Emot Brain Inst, Orangeburg, NY USA

[28] Univ So Calif, Keck Sch Med, Zilkha Neurogenat Inst, Los Angeles, CA 90033 USA

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 01期

关键词：

Sensory; Motor; Olfaction; Vision; Auditory function; Alzheimer's disease; Aging; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; CENTRAL AUDITORY DYSFUNCTION; AGE-RELATED-CHANGES; OPTICAL COHERENCE TOMOGRAPHY; EVENT-RELATED POTENTIALS; NERVE-FIBER LAYER; FRONTOTEMPORAL LOBAR DEGENERATION; TRANSCRANIAL MAGNETIC STIMULATION; TRANSGENIC MOUSE MODEL;

D O I：

10.1016/j.jalz.2014.04.514

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Recent evidence indicates that sensory and motor changes may precede the cognitive symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of developing AD. Traditionally, sensory and motor dysfunctions in aging and AD have been studied separately. To ascertain the evidence supporting the relationship between age-related changes in sensory and motor systems and the development of AD and to facilitate communication between several disciplines, the National Institute on Aging held an exploratory workshop titled "Sensory and Motor Dysfunctions in Aging and AD." The scientific sessions of the workshop focused on age-related and neuropathologic changes in the olfactory, visual, auditory, and motor systems, followed by extensive discussion and hypothesis generation related to the possible links. among sensory, cognitive, and motor domains in aging and AD. Based on the data presented and discussed at this workshop, it is clear that sensory and motor regions of the central nervous system are affected by AD pathology and that interventions targeting. amelioration of sensory-motor deficits in AD may enhance patient function as AD progresses. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：70 / 98

页数：29

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