Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

被引：104

作者：

Chen, Xianfeng ^{[1
]}

Zhang, Lin

Zhou, Kaiming

Davies, Edward

Sugden, Kate

Bennion, Ian

Hughes, Marcus

Hine, Anna

机构：

[1] Aston Univ, Sch Engn & Appl Sci, Birmingham B4 7ET, W Midlands, England

[2] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England

来源：

OPTICS LETTERS | 2007年 / 32卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1364/OL.32.002541

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability. (c) 2007 Optical Society of America.

引用

页码：2541 / 2543

页数：3

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