Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents

被引：60

作者：

Gwaltney, SL ^{[1
]}

Imade, HM ^{[1
]}

Barr, KJ ^{[1
]}

Li, Q ^{[1
]}

Gehrke, L ^{[1
]}

Credo, RB ^{[1
]}

Warner, RB ^{[1
]}

Lee, JY ^{[1
]}

Kovar, P ^{[1
]}

Wang, JY ^{[1
]}

Nukkala, MA ^{[1
]}

Zielinski, NA ^{[1
]}

Frost, D ^{[1
]}

Ng, SC ^{[1
]}

Sham, HL ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)00098-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：871 / 874

页数：4

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