Wnt signalling gets XEEKy

被引：4

作者：

Clements, WK ^{[1
]}

Kimelman, D ^{[1
]}

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 10期

关键词：

D O I：

10.1038/ncb1003-861

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The putative tumour suppressor LKB1/XEEK1 ( Xenopus egg and embryo kinase 1) has been implicated in many cellular processes and signalling pathways. Now, XEEK1 is found to exist in a complex with GSK3 ( glycogen synthase kinase 3) and protein kinase Czeta (PKCzeta), resulting in increased Wnt signal transduction during embryonic development. This discovery positions XEEK1 as a potential intersection point for crosstalk between Wnt and other pathways.

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收藏

页码：861 / 863

页数：4

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