Joint tolerance to β-lactam and fluoroquinolone antibiotics in Escherichia coli results from overexpression of hipA

被引：88

作者：

Falla, TJ

Chopra, I ^{[1
]}

机构：

[1] Univ Leeds, Dept Microbiol, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Antimicrobial Res Ctr, Leeds LS2 9JT, W Yorkshire, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 12期

关键词：

D O I：

10.1128/AAC.42.12.3282

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The basis of joint tolerance to beta-lactam and fluoroquinolone antibiotics in Escherichia coli mediated by hipA was examined. An antibiotic tolerance phenotype mas produced by overexpression of hipA under conditions that did not affect the growth rate of the organism. Overexpressing hipA probably decreases the period in which bacteria are susceptible to the antibiotics by temporarily affecting some aspect of chromosome replication or cell division.

引用

页码：3282 / 3284

页数：3

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