Evaluation of interim PET response criteria in paediatric Hodgkin's lymphoma-results for dedicated assessment criteria in a blinded dual-centre read

被引：37

作者：

Furth, C. ^{[1
]}

Amthauer, H. ^{[1
,2
]}

Hautzel, H. ^{[3
]}

Steffen, I. G. ^{[1
,2
]}

Ruf, J. ^{[1
]}

Schiefer, J. ^{[1
]}

Schoenberger, S. ^{[4
]}

Henze, G. ^{[5
]}

Grandt, R. ^{[3
]}

Hundsdoerfer, P. ^{[5
]}

Dietlein, M. ^{[6
]}

Kobe, C. ^{[6
]}

机构：

[1] Otto Von Guericke Univ, Sch Med, Dept Radiol & Nucl Med, D-39120 Magdeburg, Germany

[2] Humboldt Univ, Dept Radiol & Nucl Med, Charite Campus Virchow, Berlin, Germany

[3] Univ Dusseldorf, Dept Nucl Med KME, Res Ctr Juelich, Julich, Germany

[4] Univ Dusseldorf, Dept Paediat Oncol Haematol & Clin Immunol, Univ Childrens Hosp, Dusseldorf, Germany

[5] Humboldt Univ, Dept Paediat Oncol Haematol, Charite Campus Virchow, Berlin, Germany

[6] Univ Hosp Cologne, Dept Nucl Med, Cologne, Germany

来源：

ANNALS OF ONCOLOGY | 2011年 / 22卷 / 05期

关键词：

childhood; FDG-PET; Hodgkin's lymphoma; response assessment; response criteria; therapy monitoring; POSITRON-EMISSION-TOMOGRAPHY; FDG-PET; DISEASE; THERAPY; CHILDHOOD; CHEMOTHERAPY; CYCLES; ADOLESCENCE; NEOPLASMS;

D O I：

10.1093/annonc/mdq557

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aim of this study was to evaluate the use and reliability of the new positron emission tomography (PET)-based response criteria for interim positron emission tomography (iPET) in patients with paediatric Hodgkin's lymphoma (pHL). Particular emphasis was put on interobserver variability and on identification of a visual cut-off defining patients with very low risk for relapse. Patients and methods: The iPET scans of 39 pHL patients were evaluated in two independent centres by two PET-experienced specialists in nuclear medicine (blinded read, centre consensus) each. The iPET scans were interpreted using a 5-point scale and were compared with the outcome. Cohen's kappa-test (kappa) was used to analyse the interobserver agreement. Results: Concordant ratings were assessed in 19 patients with iPET-negative findings, in 11 patients with iPET-positive findings and in 2 patients with inconclusive ratings. A 'substantial agreement' between attended centres was achieved (kappa = 0.748). All patients suffering relapse were concordantly identified, taking mediastinal blood pool structures (MBPS) as visual cut-off between PET-positive and PET-negative findings, respectively. All pHL patients with uptake lower than or equal to MBPS remained in complete remission. Conclusion(s): The iPET interpretation assured low interobserver variability. High sensitivity for identification of pHL patients suffering relapse is achieved if [18F]-fluorodeoxyglucose uptake above the MBPS value is rated as a PET-positive finding.

引用

页码：1198 / 1203

页数：6

共 33 条

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