Expanded CAG/CTG repeats in schizophrenia - A study of clinical correlates

被引：13

作者：

Cardno, AG ^{[1
]}

Murphy, KC ^{[1
]}

Jones, LA ^{[1
]}

Guy, CA ^{[1
]}

Asherson, P ^{[1
]}

deAzevedo, MHP ^{[1
]}

Coelho, IMOD ^{[1
]}

Santos, AJFDE ^{[1
]}

Pato, CN ^{[1
]}

McGuffin, P ^{[1
]}

Owen, MJ ^{[1
]}

ODonovan, MC ^{[1
]}

机构：

[1] UNIV COIMBRA,P-3000 COIMBRA,PORTUGAL

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1996年 / 169卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1192/bjp.169.6.766

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background. Schizophrenia is associated with expanded CAG/CTG trinucleotide repeats. We wished to determine whether the presence of such expansions correlated with specific subsyndromes or other clinical features of schizophrenia. Method. Seventy patients from England and Wales and 44 patients from Portugal with a DSM-III-CR diagnosis of schizophrenia were rated on the OPCRIT checklist. Patients' maximum CAG/CTG repeat length was measured using repeat expansion detection (RED). Significant differences were sought for repeat lengths in subjects categorised according to dimensional and categorical schizophrenia subsyndromes, affective episodes, individual symptoms, and a range of demographic variables. Results. Maximum CAG/CTG repeat length did not differ significantly for any of the clinical or demographic variables studied. Conclusion. There are no subsyndromes or other clinical features of schizophrenia associated with CAG/CTG repeat expansion. Therefore, the identification of the gene(s) that contain expanded CAG/CTG repeats and which are associated with schizophrenia is unlikely to be facilitated at present by using any subsyndromes of schizophrenia as phenotypes.

引用

页码：766 / 771

页数：6

共 33 条

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