Systemic pharmacokinetics of rifaximin in volunteers with shigellosis

被引：31

作者：

Taylor, David N. ^{[1
,2
]}

McKenzie, Robin ^{[2
]}

Durbin, Anna ^{[2
]}

Carpenter, Colleen ^{[2
]}

Haake, Robert ^{[1
]}

Bourgeois, A. Louis ^{[2
]}

机构：

[1] Salix Pharmaceut Inc, Med Affairs, Morrisville, NC 27560 USA

[2] Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Immunizat Res, Dept Int Hlth, Baltimore, MD USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 03期

关键词：

D O I：

10.1128/AAC.01108-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rifaximin is an oral antibiotic indicated for treatment of traveler's diarrhea. Rifaximin pharmacokinetics were evaluated in individuals challenged with Shigella flexneri. Peak plasma rifaximin concentrations were low after nine consecutive doses, and no accumulation was observed. Rifaximin serum levels were minimal and similar to those previously reported in studies of healthy volunteers.

引用

页码：1179 / 1181

页数：3

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