Genome scan for body mass index and height in the Framingham Heart Study -: art. no. S91

被引:25
作者
Geller, F [1 ]
Dempfle, A [1 ]
Görg, T [1 ]
机构
[1] Univ Marburg, Inst Med Biometry & Epidemiol, D-35037 Marburg, Germany
关键词
D O I
10.1186/1471-2156-4-S1-S91
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Body mass index (BMI) and adult height are moderately and highly heritable traits, respectively. To investigate the genetic background of these quantitative phenotypes, we performed a linkage genome scan in the extended pedigrees of the Framingham Heart Study. Two variance-components approaches (SOLAR and MERLIN-VC) and one regression method (MERLIN-REGRESS) were applied to the data. Results: Evidence for linkage to BMI was found on chromosomes 16 and 6 with maximum LOD scores of 3.2 and 2.7, respectively. For height, all markers showing a LOD score greater than 1 in our analysis correspond to previously reported linkage regions, including chromosome 6q with a maximum LOD score of 2.45 and chromosomes 9, 12, 14, 18, and 22. Regarding the analysis, the three applied methods gave very similar results in this unselected sample with approximately normally distributed traits. Conclusion: Our analysis resulted in the successful identification of linked regions. In particular, we consider the regions on chromosomes 6 and 16 for BMI and the regions on chromosomes 6, 9, and 12 for stature interesting for fine mapping and candidate gene studies.
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页数:6
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共 14 条
[1]   Merlin-rapid analysis of dense genetic maps using sparse gene flow trees [J].
Abecasis, GR ;
Cherny, SS ;
Cookson, WO ;
Cardon, LR .
NATURE GENETICS, 2002, 30 (01) :97-101
[2]   Multipoint quantitative-trait linkage analysis in general pedigrees [J].
Almasy, L ;
Blangero, J .
AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 62 (05) :1198-1211
[3]   Factors of insulin resistance syndrome-related phenotypes are linked to genetic locations on chromosomes 6 and 7 in nondiabetic Mexican-Americans [J].
Arya, R ;
Blangero, J ;
Williams, K ;
Almasy, L ;
Dyer, TD ;
Leach, RJ ;
O'Connell, P ;
Stern, MP ;
Duggirala, R .
DIABETES, 2002, 51 (03) :841-847
[4]   A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature [J].
Deng, HW ;
Xu, FH ;
Liu, YZ ;
Shen, H ;
Deng, HY ;
Huang, QY ;
Liu, YJ ;
Conway, T ;
Li, JL ;
Davies, KM ;
Recker, RR .
AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 113 (01) :29-39
[5]   A major locus for fasting insulin concentrations and insulin resistance on chromosome 6q with strong pleiotropic effects on obesity-related phenotypes in nondiabetic Mexican Americans [J].
Duggirala, R ;
Blangero, J ;
Almasy, L ;
Arya, R ;
Dyer, TD ;
Williams, KL ;
Leach, RJ ;
O'Connell, P ;
Stern, MP .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 68 (05) :1149-1164
[6]   Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study [J].
Feitosa, MF ;
Borecki, IB ;
Rich, SS ;
Arnett, DK ;
Sholinsky, P ;
Myers, RH ;
Leppert, M ;
Province, MA .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (01) :72-82
[7]   Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height [J].
Hirschhorn, JN ;
Lindgren, CM ;
Daly, MJ ;
Kirby, A ;
Schaffner, SF ;
Burtt, NP ;
Altshuler, D ;
Parker, A ;
Rioux, JD ;
Platko, J ;
Gaudet, D ;
Hudson, TJ ;
Groop, LC ;
Lander, ES .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) :106-116
[8]   Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups [J].
Perola, M ;
Öhman, M ;
Hiekkalinna, T ;
Leppävuori, J ;
Pajukanta, P ;
Wessman, M ;
Koskenvuo, M ;
Palotie, A ;
Lange, K ;
Kaprio, J ;
Peltonen, L .
AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) :117-123
[9]   The human obesity gene map:: The 2001 update [J].
Rankinen, T ;
Pérusse, L ;
Weisnagel, SJ ;
Synder, EE ;
Chagnon, YC ;
Bouchard, C .
OBESITY RESEARCH, 2002, 10 (03) :196-243
[10]   Powerful regression-based quantitative-trait linkage analysis of general pedigrees [J].
Sham, PC ;
Purcell, S ;
Cherny, SS ;
Abecasis, GR .
AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (02) :238-253