The future of preimplantation genetic diagnosis

被引：22

作者：

Handyside, AH

Scriven, PN

Ogilvie, CM

机构：

[1] St Thomas Hosp, Dept Obstet & Gynaecol, London SE1 7EH, England

[2] Guys Hosp, Ctr Preimplantat Genet Diag, London SE1 9RT, England

来源：

HUMAN REPRODUCTION | 1998年 / 13卷

关键词：

embryo biopsy; fluorescent PCR; polar body analysis; preimplantation genetic diagnosis; reciprocal translocations;

D O I：

10.1093/humrep/13.suppl_4.249

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This paper reviews the current status of preimplantation genetic diagnosis (PGD), outlining the methods currently in use for the diagnosis of sex and single-gem defects. New approaches under development are described, e.g. fluorescent polymerase chain reaction (PCR), the use of sub-telomeric probes for patients with balanced reciprocal translocations, the analysis of first and second polar bodies, the use of lasers to facilitate the biopsy of embryos, and ways forward for infertile patients.

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页码：249 / 255

页数：7

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