Solubility of Losartan potassium in different pure solvents from (293.15 to 343.15) K

The solubility of 2-butyl-4-chloro-l-[[2'-tetrazol-5-yl)-biphenyll-4-yllmethyl-5-(hydroxymethyl) imidazole potassium in pure methanol, ethanol, I -propanol, 2-propanol, I-pentanol, ethyl acetate, butyl acetate, and cyclohexane was measured by a synthetic method over the temperature range from (293.15 to 343.15) K under atmospheric pressure. The experimental data were correlated by the modified Apelblat model. The results show that the solubility of losartan potassium increases with the increasing temperature in pure methanol, ethanol, I -propanol, and 2-propanol and decreases with the increasing temperature in I -pentanol. It is also found that losartan potassium is sparingly soluble in ethyl acetate, butyl acetate, and cyclohexane, and the solubility in these three solvents varys little with the temperature.