LIM-kinase 1

被引：57

作者：

Stanyon, CA ^{[1
]}

Bernard, O ^{[1
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1999年 / 31卷 / 3-4期

关键词：

LIM-kinase; actin cytoskeleton; GTPase; protein kinase C; protein-protein interaction;

D O I：

10.1016/S1357-2725(98)00116-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

LIM-kinasel (LIMK1) is a serine-only protein kinase that contains LIM and PDZ protein-protein interaction domains which is highly expressed in neurons. Overexpression of LIMK1 in cultured cells results in accumulation of filamentous (F-) actin. LIMK1 phosphorylates cofilin, an actin depolymerisation factor, which is then unable to bind and depolymerise F-actin. Rac-GTP enhances phosphorylation of LIMK1 and cofilin, which leads to accumulation of F-actin, while Rac-GDP and PMA reduce these effects. LIMK1 is therefore a key component of a signal transduction network that connects extracellular stimuli to changes in cytoskeletal structure. Control of cell morphology and mobility via LIMK1 activity may provide novel approaches to cancer therapy. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：389 / 394

页数：6

共 16 条

[1] Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase [J].

Arber, S ;

Barbayannis, FA ;

Hanser, H ;

Schneider, C ;

Stanyon, CA ;

Bernard, O ;

Caroni, P .

NATURE, 1998, 393 (6687) :805-809

[2]

BARBAYANNIS FA, 1998, UNPUB

[3]

BERNARD O, 1994, CELL GROWTH DIFFER, V5, P1159

[4] Structure and chromosomal localization of the genomic locus encoding the Kiz1 LIM-kinase gene [J].

Bernard, O ;

Burkitt, V ;

Webb, GC ;

Bottema, CDK ;

Nicholl, J ;

Sutherland, GR ;

Matthew, P .

GENOMICS, 1996, 35 (03) :593-596

[5] LIM domains: multiple roles as adapters and functional modifiers in protein interactions [J].

Dawid, IB ;

Breen, JJ ;

Toyama, R .

TRENDS IN GENETICS, 1998, 14 (04) :156-162

[6]

Fanning AS, 1998, CURR TOP MICROBIOL, V228, P209

[7] CYTOARCHITECTONIC ANOMALIES IN A GENETICALLY BASED DISORDER - WILLIAMS-SYNDROME [J].

GALABURDA, AM ;

WANG, PP ;

BELLUGI, U ;

ROSSEN, M .

NEUROREPORT, 1994, 5 (07) :753-757

[8] Inhibition of activated Ras-induced neuronal differentiation of PC12 cells by the LIM domain of LIM-kinase 1 [J].

Higuchi, O ;

Amano, T ;

Yang, N ;

Mizuno, K .

ONCOGENE, 1997, 14 (15) :1819-1825

[9] Mouse LIM-kinase 2 gene: cDNA cloning, genomic organization, and tissue-specific expression of two alternatively initiated transcripts [J].

Ikebe, C ;

Ohashi, K ;

Fujimori, T ;

Bernard, O ;

Noda, T ;

Robertson, EJ ;

Mizuno, K .

GENOMICS, 1997, 46 (03) :504-508

[10] cDNA cloning, genomic organization, and chromosomal localization of the mouse LIM motif-containing kinase gene, Limk2 [J].

Koshimizu, U ;

Takahashi, H ;

Yoshida, MC ;

Nakamura, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (02) :243-250

← 1 2 →