共 63 条
Extracellular signaling and multicellularity in Bacillus subtilis
被引:86
作者:

Shank, Elizabeth Anne
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机构:
Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

Kolter, Roberto
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h-index: 0
机构:
Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
机构:
[1] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA
关键词:
IMAGING MASS-SPECTROMETRY;
METABOLIC EXCHANGE;
SER/THR KINASE;
ANTIBIOTICS;
CANNIBALISM;
COMPETENCE;
PEPTIDE;
COMMUNICATION;
HETEROGENEITY;
BISTABILITY;
D O I:
10.1016/j.mib.2011.09.016
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Bacillus subtilis regulates its ability to differentiate into distinct, co-existing cell types in response to extracellular signaling molecules produced either by itself, or present in its environment. The production of molecules by B. subtilis cells, as well as their response to these signals, is not uniform across the population. There is specificity and heterogeneity both within genetically identical populations as well as at the strain-level and species-level. This review will discuss how extracellular signaling compounds influence B. subtilis multicellularity with regard to matrix-producing cannibal differentiation, germination, and swarming behavior, as well as the specificity of the quorum-sensing peptides ComX and CSF. It will also highlight how imaging mass spectrometry can aid in identifying signaling compounds and contribute to our understanding of the functional relationship between such compounds and multicellular behavior.
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收藏
页码:741 / 747
页数:7
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