Au@organosilica multifunctional nanoparticles for the multimodal imaging

被引：65

作者：

Cui, Yan ^{[1
,2
]}

Zheng, Xiao-Shan ^{[1
,2
]}

Ren, Bin ^{[1
,2
]}

Wang, Rui ^{[3
]}

Zhang, Jun ^{[3
]}

Xia, Ning-Shao ^{[3
]}

Tian, Zhong-Qun ^{[1
,2
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Lab Int Associe XiamENS,CNRS, Key Lab Analyt Sci, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[3] Xiamen Univ, Sch Life Sci, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen 361005, Peoples R China

来源：

CHEMICAL SCIENCE | 2011年 / 2卷 / 08期

关键词：

ENHANCED RAMAN-SCATTERING; ORGANIC-INORGANIC NANOPARTICLES; ONE-POT SYNTHESIS; SILICA PARTICLES; MULTIPLEX IMMUNOASSAY; GOLD NANOPARTICLES; SPECTROSCOPIC DOTS; LABELS; SERS; CELLS;

D O I：

10.1039/c1sc00242b

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The increasing application of nanomaterials in biosensor and imaging sets a higher demand on the multifunctionalities of nanomaterials for obtaining multiple parameters of a same system under a same condition. In this work, multifunctional Au@organosilica nanoparticles with high stability were conveniently synthesized by direct hydrolyzing of 3-mercaptopropyltriethoxysilane in an aqueous solution in the presence of a Au core. Modification of the Au core with Raman reporters and the organosilica shell with fluorophore before and after the hydrolysis, respectively, produces multifunctional nanoparticles exhibiting Rayleigh scattering of the Au core, fluorescence signals of the fluorophores and surface-enhanced Raman scattering (SERS) of the Raman reporters. The nanoparticles can be used as multimodal tracers for living cell imaging and related biological research.

引用

页码：1463 / 1469

页数：7

共 57 条

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