The transcription factor Pokemon:: A new key player in cancer pathogenesis

被引：85

作者：

Maeda, T ^{[1
]}

Hobbs, RM ^{[1
]}

Pandolfi, PP ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, Dept Pathol, New York, NY 10021 USA

来源：

CANCER RESEARCH | 2005年 / 65卷 / 19期

关键词：

D O I：

10.1158/0008-5472.CAN-05-1055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARE Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

引用

收藏

页码：8575 / 8578

页数：4

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