Surface-enhanced Raman scattering of single adenine molecules on silver colloidal particles

被引：66

作者：

Maruyama, Y

Ishikawa, M

Futamata, M

机构：

[1] ATP, JRCAT, Tsukuba, Ibaraki 3050046, Japan

[2] Natl Inst Adv Ind Sci & Technol, AIST, Tsukuba, Ibaraki 3058562, Japan

来源：

CHEMISTRY LETTERS | 2001年 / 08期

关键词：

D O I：

10.1246/cl.2001.834

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To find feasibility of identifying nucleotides at the single-molecule level, we implemented Raman imaging and spectroscopy of adenine molecules adsorbed on Ag colloidal nanoparticles. Surface enhanced Raman scattering (SERS) of adenine molecules showed an intermittent on-and-off behavior called "blinking". The observation of blinking provides substantial evidence for detecting single adenine molecules.

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页码：834 / 835

页数：2

相关论文

共 15 条

[1] APPLICATION OF SINGLE-MOLECULE DETECTION TO DNA-SEQUENCING AND SIZING [J].

AMBROSE, WP ;

GOODWIN, PM ;

JETT, JH ;

JOHNSON, ME ;

MARTIN, JC ;

MARRONE, BL ;

SCHECKER, JA ;

WILKERSON, CW ;

KELLER, RA ;

HACES, A ;

SHIH, PJ ;

HARDING, JD .

BERICHTE DER BUNSEN-GESELLSCHAFT-PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 1993, 97 (12) :1535-1542

[2]

Beaven G. H., 1955, NUCLEIC ACIDS, V1, P493, DOI DOI 10.1002/JPS.3030440720

[3]

BROWN R, 1996, SINGLE MOL OPTICAL D, P109

[4]

KELLER RA, 1996, APPL SPECTROSC, V50, P12

[5] Population pumping of excited vibrational states by spontaneous surface-enhanced Raman scattering [J].

Kneipp, K ;

Wang, Y ;

Kneipp, H ;

Itzkan, I ;

Dasari, RR ;

Feld, MS .

PHYSICAL REVIEW LETTERS, 1996, 76 (14) :2444-2447

[6] Single-molecule detection of a cyanine dye in silver colloidal solution using near-infrared surface-enhanced Raman scattering [J].

Kneipp, K ;

Kneipp, H ;

Deinum, G ;

Itzkan, I ;

Dasari, RR ;

Feld, MS .

APPLIED SPECTROSCOPY, 1998, 52 (02) :175-178

[7] Detection and identification of a single DNA base molecule using surface-enhanced Raman scattering (SERS) [J].

Kneipp, K ;

Kneipp, H ;

Kartha, VB ;

Manoharan, R ;

Deinum, G ;

Itzkan, I ;

Dasari, RR ;

Feld, MS .

PHYSICAL REVIEW E, 1998, 57 (06) :R6281-R6284

[8] Efficient Raman enhancement and intermittent light emission observed in single gold nanocrystals [J].

Krug, JT ;

Wang, GD ;

Emory, SR ;

Nie, SM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (39) :9208-9214

[9] Correlation between surface enhanced Raman scattering and absorbance changes in silver colloids. Evidence for the chemical enhancement mechanism [J].

Lecomte, S ;

Matejka, P ;

Baron, MH .

LANGMUIR, 1998, 14 (16) :4373-4377

[10] ADSORPTION AND SURFACE-ENHANCED RAMAN OF DYES ON SILVER AND GOLD SOLS [J].

LEE, PC ;

MEISEL, D .

JOURNAL OF PHYSICAL CHEMISTRY, 1982, 86 (17) :3391-3395