Causation of type 2 diabetes - The Gordian knot unravels

被引:36
作者
Taylor, R [1 ]
机构
[1] Univ Newcastle Upon Tyne, Sch Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词
D O I
10.1056/NEJMp038239
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:639 / 641
页数:3
相关论文
共 5 条
[1]   Preservation of pancreatic β-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk Hispanic women [J].
Buchanan, TA ;
Xiang, AH ;
Peters, RK ;
Kjos, SL ;
Marroquin, A ;
Goico, J ;
Ochoa, C ;
Tan, S ;
Berkowitz, K ;
Hodis, HN ;
Azen, SP .
DIABETES, 2002, 51 (09) :2796-2803
[2]   Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus [J].
Ek, J ;
Andersen, G ;
Urhammer, SA ;
Gæde, PH ;
Drivsholm, T ;
Borch-Johnsen, K ;
Hansen, T ;
Pedersen, O .
DIABETOLOGIA, 2001, 44 (12) :2220-2226
[3]   Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes [J].
Kelley, DE ;
He, J ;
Menshikova, EV ;
Ritov, VB .
DIABETES, 2002, 51 (10) :2944-2950
[4]   Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes:: Potential role of PGC1 and NRF1 [J].
Patti, ME ;
Butte, AJ ;
Crunkhorn, S ;
Cusi, K ;
Berria, R ;
Kashyap, S ;
Miyazaki, Y ;
Kohane, I ;
Costello, M ;
Saccone, R ;
Landaker, EJ ;
Goldfine, AB ;
Mun, E ;
DeFronzo, R ;
Finlayson, J ;
Kahn, CR ;
Mandarino, LJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8466-8471
[5]   Mitochondrial dysfunction in the elderly: Possible role in insulin resistance [J].
Petersen, KF ;
Befroy, D ;
Dufour, S ;
Dziura, J ;
Ariyan, C ;
Rothman, DL ;
DiPietro, L ;
Cline, GW ;
Shulman, GI .
SCIENCE, 2003, 300 (5622) :1140-1142