The pro-oxidant activity of aluminum

被引：334

作者：

Exley, C ^{[1
]}

机构：

[1] Univ Keele, Dept Chem, Birchall Ctr Inorgan Chem & Mat Sci, Keele ST5 5BG, Staffs, England

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 36卷 / 03期

关键词：

aluminum; pro-oxidant; superoxide; Fenton chemistry; biological oxidation; free radical;

D O I：

10.1016/j.freeradbiomed.2003.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aluminum, a non-redox-active metal is, nevertheless, a pro-oxidant both in in vitro preparations and in vivo. It facilitates both superoxide- and iron-driven biological oxidation by mechanisms that remain to be resolved. More than 10 years ago Fridovich and colleagues suggested that the facilitation of superoxide-driven biological oxidation by aluminum was due to an interaction between the metal and the superoxide radical anion (Free Radic. Biol. Med. 13:7981; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：380 / 387

页数：8

共 43 条

[1] Aluminium administration is associated with enhanced hepatic oxidant stress that may be offset by dietary vitamin E in the rat [J].