The pro-oxidant activity of aluminum

被引：334

作者：

Exley, C ^{[1
]}

机构：

[1] Univ Keele, Dept Chem, Birchall Ctr Inorgan Chem & Mat Sci, Keele ST5 5BG, Staffs, England

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 36卷 / 03期

关键词：

aluminum; pro-oxidant; superoxide; Fenton chemistry; biological oxidation; free radical;

D O I：

10.1016/j.freeradbiomed.2003.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aluminum, a non-redox-active metal is, nevertheless, a pro-oxidant both in in vitro preparations and in vivo. It facilitates both superoxide- and iron-driven biological oxidation by mechanisms that remain to be resolved. More than 10 years ago Fridovich and colleagues suggested that the facilitation of superoxide-driven biological oxidation by aluminum was due to an interaction between the metal and the superoxide radical anion (Free Radic. Biol. Med. 13:7981; 1992). This thesis has been examined herein and it is concluded that much, if not all, of the pro-oxidant activity of aluminum might be explained by the formation of an aluminum superoxide semireduced radical ion. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：380 / 387

页数：8

相关论文

共 43 条

[11] EFFECTS OF ALUMINUM ON BRAIN LIPID-PEROXIDATION [J].

FRAGA, CG ;

OTEIZA, PI ;

GOLUB, MS ;

GERSHWIN, ME ;

KEEN, CL .

TOXICOLOGY LETTERS, 1990, 51 (02) :213-219

[12] Formation of superoxide-metal ion complexes and the electron transfer catalysis [J].

Fukuzumi, S ;

Ohtsu, H ;

Ohkubo, K ;

Itoh, S ;

Imahori, H .

COORDINATION CHEMISTRY REVIEWS, 2002, 226 (1-2) :71-80

[13] COMPARISON OF THE CAPACITIES OF THE PERHYDROXYL AND THE SUPEROXIDE RADICALS TO INITIATE CHAIN OXIDATION OF LINOLEIC-ACID [J].

GEBICKI, JM ;

BIELSKI, BHJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (23) :7020-7022

[14] OXYGEN POISONING AND X-IRRADIATION - A MECHANISM IN COMMON [J].

GERSCHMAN, R ;

GILBERT, DL ;

NYE, SW ;

DWYER, P ;

FENN, WO .

SCIENCE, 1954, 119 (3097) :623-626

[15]

Gutteridge JMC, 2000, ANN NY ACAD SCI, V899, P136, DOI 10.1111/j.1749-6632.2000.tb06182.x

[16] ALUMINUM SALTS ACCELERATE PEROXIDATION OF MEMBRANE-LIPIDS STIMULATED BY IRON SALTS [J].

GUTTERIDGE, JMC ;

QUINLAN, GJ ;

CLARK, I ;

HALLIWELL, B .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 835 (03) :441-447

[17] Speciation of aluminum in biological systems [J].

Harris, WR ;

Berthon, G ;

Day, JP ;

Exley, C ;

Flaten, TP ;

Forbes, WF ;

Kiss, T ;

Orvig, C ;

Zatta, PF .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1996, 48 (06) :543-568

[18] SPERMINE ACCELERATES IRON-INDUCED LIPID-PEROXIDATION IN MITOCHONDRIA BY MODIFICATION OF MEMBRANE-SURFACE CHARGE [J].

KOGURE, K ;

FUKUZAWA, K ;

KAWANO, H ;

TERADA, H .

FREE RADICAL BIOLOGY AND MEDICINE, 1993, 14 (05) :501-507

[19] ALUMINUM(III) FACILITATES THE OXIDATION OF NADH BY THE SUPEROXIDE ANION [J].

KONG, S ;

LIOCHEV, S ;

FRIDOVICH, I .

FREE RADICAL BIOLOGY AND MEDICINE, 1992, 13 (01) :79-81

[20] ONE-ELECTRON REACTIONS IN BIOCHEMICAL SYSTEMS AS STUDIED BY PULSE RADIOLYSIS .4. OXIDATION OF DIHYDRONICOTINAMIDE-ADENINE DINUCLEOTIDE [J].

LAND, EJ ;

SWALLOW, AJ .

BIOCHIMICA ET BIOPHYSICA ACTA, 1971, 234 (01) :34-&

← 1 2 3 4 5 →