Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women

被引:44
作者
Choi, KM [1 ]
Lee, KW [1 ]
Kim, HY [1 ]
Seo, JA [1 ]
Kim, SG [1 ]
Kim, NH [1 ]
Choi, DS [1 ]
Baik, SH [1 ]
机构
[1] Korea Univ, Guro Hosp, Dept Internal Med, Div Endocrinol & Metab, Seoul 152050, South Korea
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 2005年 / 54卷 / 11期
关键词
D O I
10.1016/j.metabol.2005.05.018
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We examined the relationships among serum ferritin, alanine aminotransferase (ALT) levels, and cardiovascular risk factors of metabolic syndrome in Korean postmenopausal women. We conducted a cross-sectional study of 959 postmenopausal women without an apparent cause of liver disease. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Serum ferritin and ALT levels were found to be correlated (r = 0.374, P <.001) and to be associated with the components of metabolic syndrome. Subjects with metabolic syndrome showed significantly higher serum ferritin (74.7 +/- 2.0 vs 59.6 +/- 2.0 ng/mL, P <.001) and ALT levels (21.3 +/- 1.6 vs 18.7 +/- 1.5 IU/L, P <.001). Moreover, the greater the number of metabolic syndrome components present, the higher were the serum ferritin and ALT levels (P <.001). Multiple regression analysis showed that serum ALT levels are significantly associated with serum ferritin levels, waist circumference, fasting blood glucose, age, and white blood cell count (adjusted R-2 = 0.147). Elevated iron stores were positively associated with serum ALT levels and metabolic syndrome in Korean postmenopausal women. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:1510 / 1514
页数:5
相关论文
共 34 条
[1]   Medical progress: Disorders of iron metabolism [J].
Andrews, NC .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (26) :1986-1995
[2]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[3]   Prospective evaluation of unexplained chronic liver transaminase abnormalities in asymptomatic and symptomatic patients [J].
Daniel, S ;
Ben-Menachem, T ;
Vasudevan, G ;
Ma, CK ;
Blumenkehl, M .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (10) :3010-3014
[4]  
DAVIS RJ, 1986, J BIOL CHEM, V261, P8708
[5]   Steatohepatitis: A tale of two "hits"? [J].
Day, CP ;
James, OFW .
GASTROENTEROLOGY, 1998, 114 (04) :842-845
[6]  
DeMaeyer E, 1985, World Health Stat Q, V38, P302
[7]   Clinical features and natural history of nonalcoholic steatosis syndromes [J].
Falck-Ytter, Y ;
Younossi, ZM ;
Marchesini, G ;
McCullough, AJ .
SEMINARS IN LIVER DISEASE, 2001, 21 (01) :17-26
[8]   Serum ferritin as a component of the insulin resistance syndrome [J].
Fernández-Real, JM ;
Ricart-Engel, W ;
Arroyo, E ;
Balançá, R ;
Casamitjana-Abella, R ;
Cabrero, D ;
Fernández-Castañer, M ;
Soler, J .
DIABETES CARE, 1998, 21 (01) :62-68
[9]   Insulin resistance, iron, and the liver [J].
Ferrannini, E .
LANCET, 2000, 355 (9222) :2181-2182
[10]   Alcohol consumption and the prevalence of the metabolic syndrome in the US - A cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey [J].
Freiberg, MS ;
Cabral, HJ ;
Heeren, TC ;
Vasan, RS ;
Ellison, RC .
DIABETES CARE, 2004, 27 (12) :2954-2959