No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

被引：27

作者：

Petrill, SA

Plomin, R

McClearn, GE

Smith, DL

Vignetti, S

Chorney, MJ

Chorney, K

Thompson, LA

Detterman, DK

Benbow, C

Lubinski, D

Daniels, J

Owen, M

McGuffin, P

机构：

[1] INST PSYCHIAT, LONDON, ENGLAND

[2] PENN STATE UNIV, MILTON S HERSHEY MED CTR, UNIVERSITY PK, PA 16802 USA

[3] CASE WESTERN RESERVE UNIV, CLEVELAND, OH 44106 USA

[4] IOWA STATE UNIV, AMES, IA 50011 USA

[5] UNIV WALES COLL MED, CARDIFF CF4 4XN, S GLAM, WALES

来源：

BEHAVIOR GENETICS | 1997年 / 27卷 / 01期

关键词：

intelligence; D2 dopamine receptor; spatial ability; quantitative trait loci; association; DNA MARKERS; LOW IQ; PROJECT;

D O I：

10.1023/A:1025659124405

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

引用

页码：29 / 31

页数：3

共 9 条

[1] REDUCED VISUOSPATIAL PERFORMANCE IN CHILDREN WITH THE D2 DOPAMINE-RECEPTOR A1 ALLELE [J].