Enantioselective hydrogenation with racemic and enantiopure binap in the presence of a chiral ionic liquid

被引：61

作者：

Chen, Dianjun ^{[1
]}

Schmitkamp, Mike ^{[1
]}

Francio, Giancarlo ^{[1
]}

Klankermayer, Juergen ^{[1
]}

Leitner, Walter ^{[1
,2
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Tech & Makromol Chem, D-52074 Aachen, Germany

[2] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 38期

关键词：

chirality; hydrogenation; ionic liquids; rhodium;

D O I：

10.1002/anie.200801995

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Racemic but enantioselective: rac-Binap and a chiral ionic liquid (cIL) used for the asymmetric hydrogenation of dimethyl itaconate led to identical ee values as enantiopure binap. The enantiodifferentiation results primarily from a diastereomeric interaction of the binap-Rh unit and the proline ester moiety. For other substrates, enhanced enantioselectivity with inverted absolute configuration was obtained with the enantiopure ligand in the cIL relative to organic solvents. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7339 / 7341

页数：3

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