Titanium(IV) alkoxide ligand exchange with α-hydroxy acids:: The enantioselective aldol addition

被引：33

作者：

Mahrwald, R ^{[1
]}

机构：

[1] Humboldt Univ, Inst Organ & Bioorgan Chem, D-10115 Berlin, Germany

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 25期

关键词：

D O I：

10.1021/ol0002727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ligand exchange of titanium(IV) alkoxides with alpha -hydroxy acids presents an unexpected and novel approach to enantioselective aldol additions of aldehydes and ketones. The aldol products were isolated in a high degree of syn-diastereoselectivity. High enantioselectivities were observed by using simple optically pure alpha -hydroxy acids in this novel aldol addition.

引用

页码：4011 / 4012

页数：2

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