Regression of albuminuria: latest evidence for a new approach

Objective: To review the latest studies on anti hypertensive strategies in the treatment of microalbuminuria, in order to highlight the association of microalbuminuria with hypertension and type 2 diabetes, the evidence for microalbuminuria as a risk factor for target-organ damage and mortality, and the prognostic significance of regression of microalbuminuria. Study selection: Randomized controlled trials in patients with hypertension, type 2 (non-insulin-dependent) diabetes mellitus and microalbuminuria, with changes in albumin excretion rate (AER) as a primary outcome measure. Results of data analysis: Antihypertensive treatment is the most effective method for reducing microalbuminuria. Although microalbuminuria regression is related to reduction in blood pressure, antihypertensive drugs acting on the renin-angiotensin system have an antiproteinuric effect that is additional to that of blood pressure reduction. The combination of these agents with diuretics, even when used in low doses, may further reduce AER in these patients. Conclusions: Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers is a most effective means of treating microalbuminuria and preventing its progression to overt nephropathy and, perhaps, the associated cardiovascular disease. The effect of this strategy may be improved further with the use, as first-line treatment, of a combination of angiotensin-converting enzyme inhibitor and diuretic. (C) 2003 Lippincott Williams Wilkins.