Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice

被引：71

作者：

Carlos da Silva, Francisca Charliane ^{[1
]}

de Oliveira Cito, Maria do Carmo ^{[1
]}

Comes da Silva, Maria Izabel ^{[1
]}

Moura, Brinell Arcanjo ^{[1
]}

de Aquino Neto, Manuel Rufino ^{[1
]}

Feitosa, Mariana Lima ^{[1
]}

Chaves, Raquell de Castro ^{[1
]}

Macedo, Danielle Silveira ^{[1
]}

Mendes de Vasconcelos, Silvania Maria ^{[1
]}

de Franca Fonteles, Marta Maria ^{[2
]}

Florenco de Sousa, Francisca Clea ^{[1
]}

机构：

[1] Univ Fed Ceara, Neuropharmacol Lab, Dept Physiol & Pharmacol, Sch Med, BR-60430270 Fortaleza, Ceara, Brazil

[2] Univ Fed Ceara, Dept Pharm, Sch Pharm Dent & Nursing, BR-60431327 Fortaleza, Ceara, Brazil

来源：

BRAIN RESEARCH BULLETIN | 2010年 / 83卷 / 1-2期

关键词：

Ketamine; Anxiety; Depression; Behavior; Oxidative stress; TOTAL ANTIOXIDANT CAPACITY; D-ASPARTATE ANTAGONIST; OXIDATIVE STRESS; NITRIC-OXIDE; RECEPTOR ANTAGONISTS; PATHOPHYSIOLOGICAL ROLE; PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; NMDA RECEPTORS; PLUS-MAZE;

D O I：

10.1016/j.brainresbull.2010.05.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A growing body of evidence has pointed to the ionotropic glutamate N-methyl-D-aspartate receptor (NMDA) as an important player in the etiology of psychopathologies, including anxiety and major depression. Clinical findings suggest that ketamine may be used for the treatment of major depression. There is evidence that reactive oxygen species also play an important role in the pathogenesis of many diseases, particularly those which are neurological and psychiatric in nature. This study examined the behavioral and oxidative stress alterations after a single administration of ketamine (5, 10 and 20 mg/kg i.p.) in mice. Ketamine presented a significant anxiogenic effect in the elevated plus-maze model of anxiety, also increasing locomotor activity. In the forced swimming and tail suspension tests, a significant decrease in immobility time after ketamine administration was observed. In addition to the behavioral changes induced by ketamine, this drug also increased lipid peroxidation, nitrite content and catalase activity, while decreased GSH levels in mice prefrontal cortex. In conclusion, our results confirm the antidepressant effects of ketamine, also showing a pro-oxidant effect of this drug. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：9 / 15

页数：7

共 69 条

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